Gene name:
Notch1 (Motch) ;
Protein name:
Neurogenic locus notch homolog protein 1 (Notch 1) ;
Alternative:
mT14 ;Motch A ;p300 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.
Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Subcellular Location:
Notch 1 intracellular domain
Nucleus
Following proteolytical processing NICD is translocated to the nucleus.
Protein Attributes:
50:
MPRLLTPLLC | LTLLPARAAR | GLRCSQPSGT | CLNGGRCEVA | SGTEACVASG |
100:
SFVGQRCQDP | NPCLSTRCKN | AGTCYVVDHG | GIVDYACSCP | LGFSGPLCLT |
150:
PLDKPCLANP | CRNGGTCDLL | TLTEYKCRCS | PGWSGKSCQQ | ADPCASNPCA |
200:
NGGQCLPFES | SYICRCPPGF | HGPTCRQDVN | ECSQNPGLCR | HGGHCHNEIG |
250:
SYRCACCATH | TGPHCELPYV | PCSPSPCQNG | ATCRPTGDTT | HECACLPGFA |
300:
GQNCEENVDD | CPGNNCKNGG | ACVDGVNTYN | CRCPPEVTGQ | YCTEDVDECQ |
350:
LMPNACQNAG | TCHNTHGGYN | CVCVNGWTGE | DCSENIDDCA | SAACFQGATC |
400:
HDRVASFYCE | CPHGRTGLLC | HLKHACISNP | CNEGSNCDTN | PVNGKRICTC |
450:
PSGYTGPACS | QDVDECDLGA | NRCEHAGKCL | NTLGSFECQC | LQGYTGPGCE |
500:
IDVNECISNP | CQNDATCLDQ | IGEFQCICMP | GYEGVYCEIN | TDECASSPCL |
550:
HNGHCMDKIH | EFQCQCPKGF | NGHLCQYDVD | ECASTPCKNG | AKCLDGPNTY |
600:
TCVCTEGYTG | THCEVDIDEC | DPDPCHYGSC | KDGVATFTCL | CQPGYTGHHC |
650:
ETNINECHSQ | PCRHGGTCQD | RDNSYLCLCL | KGTTGPNCEI | NLDDCASNPC |
700:
DSGTCLDKID | GYECACEPGY | TGSMCNVNID | ECAGSPCHNG | GTCEDGIAGF |
750:
TCRCPEGYHD | PTCLSEVNEC | NSNPCIHGAC | RDGLNGYKCD | CAPGWSGTNC |
800:
DINNNECESN | PCVNGGTCKD | MTSGYVCTCR | EGFSGPNCQT | NINECASNPC |
850:
LNQGTCIDDV | AGYKCNCPLP | YTGATCEVVL | APCATSPCKN | SGVCKESEDY |
900:
ESFSCVCPTG | WQGQTCEVDI | NECVKSPCRH | GASCQNTNGS | YRCLCQAGYT |
950:
GRNCESDIDD | CRPNPCHNGG | SCTDGINTAF | CDCLPGFQGA | FCEEDINECA |
1000:
SNPCQNGANC | TDCVDSYTCT | CPVGFNGIHC | ENNTPDCTES | SCFNGGTCVD |
1050:
GINSFTCLCP | PGFTGSYCQY | DVNECDSRPC | LHGGTCQDSY | GTYKCTCPQG |
1100:
YTGLNCQNLV | RWCDSAPCKN | GGRCWQTNTQ | YHCECRSGWT | GVNCDVLSVS |
1150:
CEVAAQKRGI | DVTLLCQHGG | LCVDEGDKHY | CHCQAGYTGS | YCEDEVDECS |
1200:
PNPCQNGATC | TDYLGGFSCK | CVAGYHGSNC | SEEINECLSQ | PCQNGGTCID |
1250:
LTNSYKCSCP | RGTQGVHCEI | NVDDCHPPLD | PASRSPKCFN | NGTCVDQVGG |
1300:
YTCTCPPGFV | GERCEGDVNE | CLSNPCDPRG | TQNCVQRVND | FHCECRAGHT |
1350:
GRRCESVING | CRGKPCKNGG | VCAVASNTAR | GFICRCPAGF | EGATCENDAR |
1400:
TCGSLRCLNG | GTCISGPRSP | TCLCLGSFTG | PECQFPASSP | CVGSNPCYNQ |
1450:
GTCEPTSENP | FYRCLCPAKF | NGLLCHILDY | SFTGGAGPDI | PPPQIEEACE |
1500:
LPECQVDAGN | KVCNLQCNNH | ACGWDGGDCS | LNFNDPWKNC | TQSLQCWKYF |
1550:
SDGHCDSQCN | SAGCLFDGFD | CQLTEGQCNP | LYDQYCKDHF | SDGHCDQGCN |
1600:
SAECEWDGLD | CAEHVPERLA | AGTLVLVVLL | PPDQLRNNSF | HFLRELSHVL |
1650:
HTNVVFKRDA | QGQQMIFPYY | GHEEELRKHP | IKRSTVGWAT | SSLLPGTSGG |
1700:
RQRRELDPMD | IRGSIVYLEI | DNRQCVQSSS | QCFQSATDVA | AFLGALASLG |
1750:
SLNIPYKIEA | VKSEPVEPPL | PSQLHLMYVA | AAAFVLLFFV | GCGVLLSRKR |
1800:
RRQHGQLWFP | EGFKVSEASK | KKRREPLGED | SVGLKPLKNA | SDGALMDDNQ |
1850:
NEWGDEDLET | KKFRFEEPVV | LPDLSDQTDH | RQWTQQHLDA | ADLRMSAMAP |
1900:
TPPQGEVDAD | CMDVNVRGPD | GFTPLMIASC | SGGGLETGNS | EEEEDAPAVI |
1950:
SDFIYQGASL | HNQTDRTGET | ALHLAARYSR | SDRRKRLEAS | ADANIQDNMG |
2000:
RTPLHAAVSA | DAQGVFQILL | RNRATDLDAR | MHDGTTPLIL | AARLAVEGML |
2050:
EDLINSHADV | NAVDDLGKSA | LHWAAAVNNV | DAAVVLLKNG | ANKDIENNKE |
2100:
ETSLFLSIRR | ESYETAKVLL | DHFANRDITD | HMDRLPRDIA | QERMHHDIVR |
2150:
LLDEYNLVRS | PQLHGTALGG | TPTLSPTLCS | PNGYPGNLKS | ATQGKKARKP |
2200:
STKGLACGSK | EAKDLKARRK | SSQDGKGWLL | DSSSSMLSPV | DSLESPHGYL |
2250:
SDVASHPLLP | SPFQQSPSMP | LSHLPGMPDT | HLGISHLNVA | AKPEMAALAG |
2300:
GSRLAFEHPP | PRLSHLPVAS | SACTVLSTNG | TGAMNFTVGA | PASLNGQCEW |
2350:
LPRLQNGMVP | SQYNPLRPGV | TPGTLSTQAA | GLQHSMMGPL | HSSLSTNTLS |
2400:
PIIYQGLPNT | RLATQPHLVQ | TQQVQPQNLP | LQPQNLQPPS | QPHLSVSSAA |
2450:
NGHLGRSFLS | GEPSQADVQP | LGPSSLPVHT | ILPQESQALP | TSLPSSMVPP |
2500:
MTTTQFLTPP | SQHSYSSSPV | DNTPSHQLQV | PEPTFLTPSP | ESPDQWSSSS |
2531:
PHSNISDWSE | GISSPPTTMP | SQITHIPEAF | K
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Notch 1
ELISA Kit for Mouse Notch 1
ELISA Kit for Mouse Notch 1
CLIA Kit for Mouse Notch 1
CLIA Kit for Mouse Notch 1
CLIA Kit for Mouse Notch 1
Polyclonal Antibody for Mouse Notch 1
Polyclonal Antibody for Mouse Notch 1
Polyclonal Antibody for Mouse Notch 1
Monoclonal Antibody for Mouse Notch 1
Monoclonal Antibody for Mouse Notch 1
Monoclonal Antibody for Mouse Notch 1
Protein for Mouse Notch 1
Protein for Mouse Notch 1
Protein for Mouse Notch 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 731-1899 (ISOFORM 2);DEVELOPMENTAL STAGE
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CD-1 .
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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C57BL/6 X CBA .
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1373-2531
strain :
NOD .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1551-1647 (ISOFORM 1);DEVELOPMENTAL STAGE
tissue :
Embryo .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1655-1659;CLEAVAGE BY FURIN-LIKE CONVERTASE;MUTAGENESIS OF 1651-ARG--ARG-1654
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1865-2076;DEVELOPMENTAL STAGE IN HAIR FOLLICLES
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1937-1952 AND 1995-2019;FUNCTION;INTERACTION WITH HIF1AN;HYDROXYLATION AT ASN-1945 AND ASN-2012 BY HIF1AN;MUTAGENESIS OF ASN-1945 AND ASN-2012;IDENTIFICATION BY MASS SPECTROMETRY
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1951-2201
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;PROTEOLYTIC PROCESSING
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING
19.
"Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis."
Kishi N.
,
Tang Z.
,
Maeda Y.
,
Hirai A.
,
Mo R.
,
Ito M.
,
Suzuki S.
,
Nakao K.
,
Kinoshita T.
,
Kadesch T.
,
Hui C.-C.
,
Artavanis-Tsakonas S.
,
Okano H.
,
Matsuno K.
Int. J. Dev. Neurosci.19:21-35(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DTX1 AND DTX2
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAML1
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION AT LYS-1749;ENDOCYTOSIS
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DNER;FUNCTION;TISSUE SPECIFICITY
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION BY ITCH
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AAK1
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT SER-65; THR-73; THR-116; SER-146; THR-194; SER-341; SER-378; SER-458; THR-466; SER-496; SER-534; SER-609; SER-647; SER-722; SER-759; THR-767; SER-797; THR-805; SER-951; SER-1027; THR-1035; SER-1065; SER-1189; THR-1197; SER-1273 AND THR-1362;MUTAGENESIS OF SER-65; SER-146; SER-341; SER-378; SER-458; SER-496; SER-534; SER-609; SER-647; SER-722; SER-759; SER-797; SER-951; SER-1027; SER-1065; SER-1189 AND SER-1273
26.
"BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets."
Tiberi L.
,
van den Ameele J.
,
Dimidschstein J.
,
Piccirilli J.
,
Gall D.
,
Herpoel A.
,
Bilheu A.
,
Bonnefont J.
,
Iacovino M.
,
Kyba M.
,
Bouschet T.
,
Vanderhaeghen P.
Nat. Neurosci.15:1627-1635(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS NEUROGENESIS REPRESSOR;INTERACTION WITH BCL6
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH THBS4
28.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1971-2104
29.
"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L.
,
McDonough M.A.
,
Hewitson K.S.
,
Coles C.
,
Mecinovic J.
,
Edelmann M.
,
Cook K.M.
,
Cockman M.E.
,
Lancaster D.E.
,
Kessler B.M.
,
Oldham N.J.
,
Ratcliffe P.J.
,
Schofield C.J.
J. Biol. Chem.282:24027-24038(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1899-2106 IN COMPLEX WITH HIF1AN; IRON AND 2-OXOGLUTARATE;HYDROXYLATION AT ASN-1945 AND ASN-2012;MUTAGENESIS OF ASN-1945 AND ASN-2012;IDENTIFICATION BY MASS SPECTROMETRY